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Simulated moving bed chromatography

Simulated moving bed chromatography

 

Simulated Moving Bed (SMB) Chromatography: Unlocking Efficiency in Separation and Purification

Simulated Moving Bed (SMB) technology revolutionizes chromatographic separation by offering continuous purification with remarkable advantages over traditional batch methods. Here’s why SMB deserves the spotlight:

  1. Continuous Purity: SMB ensures consistent product quality by continuously separating chemical compounds. Unlike batch chromatography, which can be time-consuming and costly, SMB achieves desired product purity efficiently.
  2. Less Solvent Consumption: By optimizing solvent usage, SMB reduces environmental impact and operational costs. It’s a greener alternative for industrial chemical production.
  3. Higher Throughput: SMB’s continuous flow design allows for increased production rates. Whether you’re extracting products from biorefinery fermentation or refining industrial chemicals, SMB delivers.
  4. Carbon-Neutral Potential: SMB aligns with the quest for sustainable practices. Researchers are exploring its application in economically viable and environmentally friendly chemical production.

Explore the power of SMB – where precision meets productivity.

 

Here are couple of systems we offer:

SMB system for lab scale:

The AZURA Lab SMB System is optimized for the multicolumn separation of binary mixtures of small molecules in gram-scale. The SMB System A29101 is the standard stainless steel configuration of our AZURA Lab SMB. It consists of seven 8-multiposition valves and four AZURA P 4.1S included in four Assitants ASM 2.2L. The high pressure range as well as the flexibility of the multiposition valves make this system the perfect solution for SMB chromatography.

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.

System and process control: A29800 (one CORI-FLOW), A29801 (four CORI-FLOW)

Heating and column organisation: A29903 (oven), A29901 (column holder ID 50), A29902 (for columns with 8, 16 or 20mm ID)

 

 

SMB process digram 1

 

SMB process diagram 2

TECHNICAL DATA

AZURA SMB systems

Recommended flow rate 2-30 ml/min
Continuous working conditions 3−25 ml/min
Recommended Feed flow 0.1−4.0 ml/min
Maximum delivery pressure [bar] 130 bar
Maximum viscosity 100 cP
Column dimensions up to 30 mm ID
Column configuration 2:2:2:2, 1:1:1:1, 1:3:3:1
Operating modes SMB
Supported software packages PurityChrom® MCC
Wetted materials PAEK, FKM, GFP (graphite fiber reinforced PTFE), PEEKPTFEstainless steelrubysapphireTitaniumAluminiumoxid (Al2O3)Zirconium oxide

Do you need more information or looking for other SMB systems, for instance bio-compatible SMBs, please visit our supplier website or contact us for more information:

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